Preanalytical (Mis)Handling of Plasma Investigated by ¹H NMR Metabolomics.

ABSTRACT: The preanalytical handling of plasma, how it is drawn, processed, and stored, influences its composition. Samples in biobanks often lack this information and, consequently, important information about their quality. Especially metabolite concentrations are affected by preanalytical handling, making conclusions from metabolomics studies particularly sensitive to misinterpretations. The perturbed metabolite profile, however, also offers an attractive choice for assessing the preanalytical history from the measured data. Here we show that it is possible using Orthogonal Projections to Latent Structures Discriminative Analysis to divide plasma NMR data into a multivariate "original sample space" suitable for further less biased metabolomics analysis and an orthogonal "preanalytical handling sp

SUBMITTER: Malmodin D 

PROVIDER: S-EPMC11635485 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature