Supercritical CO₂-Mediated Decellularization of Bovine Spinal Cord Meninges: A Comparative Study for Decellularization Performance.

ABSTRACT: The extracellular matrix (ECM) of spinal meninge tissue closely resembles the wealthy ECM content of the brain and spinal cord. The ECM is typically acquired through the process of decellularizing tissues. Nevertheless, the decellularization process of the brain and spinal cord is challenging due to their high-fat content, in contrast to the spinal meninges. Hence, bovine spinal cord meninges offer a promising source to produce ECM-based scaffolds, thanks to their abundance, accessibility, and ease of decellularization for neural tissue engineering. However, most decellularization techniques involve disruptive chemicals and repetitive rinsing processes, which could lead to drastic modifications in the tissue ultrastructure and a loss of mechanical stability. Over the past decade, supercrit

SUBMITTER: Ozudogru E 

PROVIDER: S-EPMC11635505 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature