Development and validation of a risk score model for patient stratification and personalized management of papillary thyroid cancer.

ABSTRACT:

Background

The status of central lymph node (CLN) is a crucial determinant for the initial treatment of papillary thyroid cancer (PTC), but preoperative ultrasound (US) has limited ability to accurately assess their condition. This study aimed to develop a risk score model for risk stratification of CLN metastasis in unifocal PTC patients to guide the initial treatment.

Methods

A total of 5,374 patients diagnosed with unifocal PTC at Union Hospital between November 2009 and August 2022 were finally enrolled in the analysis, including 3,542 patients in derivation cohort and 1,832 patients in validation cohort. Stepwise multivariable logistic regression was used to build the risk score of CLN metastasis. Risk score weights were assigned by dividing the coefficients of the pred

SUBMITTER: Guo H 

PROVIDER: S-EPMC11635556 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature