Comparison of clinical characteristics and pathologic complete response rate after neoadjuvant chemotherapy in women under 35 years and older women with breast cancer.

ABSTRACT:

Background

Age has been confirmed as a very aggressive biological factor associated with the poor prognosis of breast cancer (BC) patients. However, the understanding of young women with breast cancer (YWBC) is scarce. This study compares and evaluates the clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy (NAC) in YWBC and older women with BC.

Methods

We retrospectively analyzed the clinicopathological data and pCR rates of 1,419 non-metastatic BC patients from the Harbin Medical University Cancer Hospital from 1 January 2012 to 31 December 2019. Patients were classified according to age (≤35 vs. >35 years old) with the clinical parameters. The chi-squared or Fisher's exact test was used to evaluate the correlation bet

SUBMITTER: Dou H 

PROVIDER: S-EPMC11635561 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature