Causal effects of thyroid volume change on thyroid disease: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested an association between thyroid volume changes and thyroid disease, but the causal relationship and direction of these effects remain unclear. This study employs a two-sample Mendelian randomization (MR) approach to assess the effect of thyroid volume on clinically common benign and malignant thyroid diseases.

Methods

Summary data from genome-wide association studies (GWAS) were utilized for secondary data analysis to investigate the link between thyroid volume and disease. Gene loci strongly associated with thyroid volume were selected as the instrumental variables. Five complementary two-sample MR methods were used to evaluate the causal effect of thyroid volume on thyroid diseases and thyroid stimulating hormone (TSH).

Res

SUBMITTER: Yuan H 

PROVIDER: S-EPMC11635569 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature