Parental age at birth and biomarkers of fecundity in young Danish men.

ABSTRACT:

Background

High parental age is associated with adverse birth and genetic outcomes, but little is known about fecundity in male offspring.

Objectives

We investigated if high parental age at birth was associated with biomarkers of male fecundity in a large population-based sample of young men.

Materials and methods

We conducted a study of 1057 men from the Fetal Programming of Semen Quality (FEPOS) cohort, a sub-cohort of sons born 1998-2000 into the Danish National Birth Cohort. Semen characteristics and reproductive hormone concentrations were measured in samples provided by the men 2017-2019. Testis volume was determined by self-measurement. Data on the parental age was drawn from registers. Adjusted relative difference in percentage with 95% confidence intervals we

SUBMITTER: Ernst A 

PROVIDER: S-EPMC11635595 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature