Comprehensive analysis of selenoprotein gene expression and prognostic value in ovarian cancer.

ABSTRACT:

Objective

To comprehensively analyze the expression and prognostic value of selenoprotein in ovarian cancer (OV).

Materials and methods

GEPIA and cBioPortal were used to analyze selenoprotein expression and mutations and copy number variations. Kaplan-Meier plotter and the tumor immune estimation resource were used to evaluate the impact of these genes on clinical prognosis and their correlation with tumor immune infiltration.

Results

Compared with normal tissues, the expression of iodothyronine deiodinase 3 (DIO3), glutathione peroxidase 4, SECISBP2, SELM, and SELP was decreased in the four gynecological malignancies. In OV, selenoprotein had the highest number of mutations (309) and mutation frequency (52.91%), whereas the lowest was observed in endometrial cancer (

SUBMITTER: Hou Y 

PROVIDER: S-EPMC11635729 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature