Mucosal vaccination with outer membrane vesicles derived from <i>Bordetella pertussis</i> reduces nasal bacterial colonization after experimental infection.

ABSTRACT:

Introduction

We previously identified Bordetella pertussis-derived outer membrane vesicles (OMVs) as a promising immunogen for improving pertussis vaccines. In this study, we evaluated the efficacy of our vaccine prototype in immunization strategies aimed at reducing disease transmission by targeting colonization in the upper airways while maintaining protection against severe disease by reducing colonization in the lower respiratory tract.

Methods

We assessed different mucosal administration strategies in a murine model, including homologous mucosal 2-dose prime-boost schedules and heterologous prime-boost strategies combining intramuscular (IM) systemic immunization with mucosal routes (intranasal, IN; or sublingual, SL). We utilized alum and c-di-AMP as adjuvants f

SUBMITTER: Rudi E 

PROVIDER: S-EPMC11635837 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature