CSF levels of brain-derived proteins correlate with brain ventricular volume in cognitively healthy 70-year-olds.

ABSTRACT:

Background

The effect of varying brain ventricular volume on the cerebrospinal fluid (CSF) proteome has been discussed as possible confounding factors in comparative protein level analyses. However, the relationship between CSF volume and protein levels remains largely unexplored. Moreover, the few existing studies provide conflicting findings, indicating the need for further research.

Methods

Here, we explored the association between levels of 88 pre-selected CSF proteins and ventricular volume derived from magnetic resonance imaging (MRI) measurements in 157 cognitively healthy 70-year-olds from the H70 Gothenburg Birth Cohort Studies, including individuals with and without pathological levels of Alzheimer's disease (AD) CSF markers (n = 123 and 34, respectively). Both lef

SUBMITTER: Bergstrom S 

PROVIDER: S-EPMC11636040 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature