Cancer specific up-regulated lactate genes associated with immunotherapy resistance in a pan-cancer analysis.

ABSTRACT:

Background

Although the lactate pathway has been reported to lead to immune escape through the inhibition of effector T cells, the cancer-intrinsic lactate signature has not been identified, and the immunotherapeutic efficacy and potential mechanism of the lactate signature are still unclear.

Methods

We defined a pan-cancer up-lactate score by comparing malignant tissues and normal tissues in the TCGA cohort. The immunotherapeutic efficacy was evaluated in non-small cell lung cancer (NSCLC), metastatic renal cancer (mRCC), bladder cancer (BLCA) and melanoma cohorts. The cancer cell-intrinsic mechanism to immune checkpoint inhibitors (ICIs) resistance was measured using single cell sequencing (scRNA-seq) data. Pathway activation was evaluated in the TCGA cohort and CPTAC coho

SUBMITTER: Fu S 

PROVIDER: S-EPMC11636123 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature