Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders.

ABSTRACT: Obesity is a major contributor to metabolic and cardiovascular disease. Although senescent cells have been shown to accumulate in adipose tissue, the role of senescence in obesity-induced metabolic disorders and in cardiac dysfunction is not yet clear; therefore, the therapeutic potential of managing senescence in obesity-related metabolic and cardiac disorders remains to be fully defined.

Objective

We investigated the beneficial effects of a senolytic cocktail (dasatinib and quercetin) on senescence and its influence on obesity-related parameters.

Methods and results

We found that the increase in body weight and adiposity, glucose intolerance, insulin resistance, dyslipidemia, hyperleptinemia, and hepatic disorders which were induced by an obesogenic diet were alleviated by

SUBMITTER: de Oliveira Silva T 

PROVIDER: S-EPMC11636344 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature