The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment.

ABSTRACT:

Background

Cluster of differentiation 47 (CD47), a transmembrane protein, plays a critical role in regulating cellular functions and maintaining immune homeostasis. Its expression has been shown to influence cancer prognosis. In this study, we investigated the role of CD47 in tumor progression in colon adenocarcinoma (COAD) and evaluated its potential as a target for immunotherapy.

Materials and methods

We analyzed surgical samples from 96 COAD patients. Immunohistochemical analysis was performed on 90 samples, while the remaining 6 were subjected to multiplex immunofluorescence. To explore the association between CD47 expression and clinicopathological characteristics, we integrated transcriptome data from The Cancer Genome Atlas and the Gene Expression Omnibus using R soft

SUBMITTER: Tian QS 

PROVIDER: S-EPMC11636535 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature