Quantifying the Corneal Nerve Whorl Pattern.

ABSTRACT:

Purpose

The corneal nerves within the sub-basal nerve plexus (SBNP) display a distinctive whorl-like pattern, a highly dynamic structure that could be a marker of diseases. Previous studies have reported a decrease in whorl nerve density in patients with diabetes, indicating an avenue for noninvasive monitoring of diabetic neuropathy. However, conflicting results have since been reported, highlighting the need for improved quantitative analysis of the corneal whorl. We present an automated algorithm to characterize the whorl shape and test the hypothesis that the whorl organization is affected by diabetic neuropathy.

Methods

The SBNP whorl was analyzed as a vector field, from which seven whorl metrics were calculated. The efficacy of these whorl metrics was demonstrated in s

SUBMITTER: Lapierre-Landry M 

PROVIDER: S-EPMC11636656 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature