Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation.

ABSTRACT:

Purpose

The purpose of this study was to quantitatively evaluate the branching patterns and vascular fragmentation features in preclinical and early diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA).

Methods

OCTA metrics, including branch node number (BNN), branch node density (BND), end point number (EPN), end point density (EPD), fragmented vessel segment count (FVSC), and fragmented vascular length ratio (FVLR), were measured in foveal and parafoveal regions within superficial and deep vascular plexus (SVP and DVP) in the retina.

Results

Compared to healthy control (HCs), both BNN and BND exhibited a significant decrease in individuals with mild DR across both retinal layers, and also in diabetes mellitus without DR (no DR) within DVP.

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11636659 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature