Mathematical model of voluntary vaccination against schistosomiasis.

ABSTRACT: Human schistosomiasis is a chronic and debilitating neglected tropical disease caused by parasitic worms of the genus Schistosoma. It is endemic in many countries in sub-Saharan Africa. Although there is currently no vaccine available, vaccines are in development. In this paper, we extend a simple compartmental model of schistosomiasis transmission by incorporating the vaccination option. Unlike previous models of schistosomiasis transmission that focus on control and treatment at the population level, our model focuses on incorporating human behavior and voluntary individual vaccination. We identify vaccination rates needed to achieve herd immunity as well as optimal voluntary vaccination rates. We demonstrate that the prevalence remains too high (higher than 1%) unless the vaccination co

SUBMITTER: Lopez S 

PROVIDER: S-EPMC11636677 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature