Predicting the effect of micro-stimulation on macaque prefrontal activity based on spontaneous circuit dynamics.

ABSTRACT: A crucial challenge in targeted manipulation of neural activity is to identify perturbation sites whose stimulation exerts significant effects downstream with high efficacy, a procedure currently achieved by labor-intensive and potentially harmful trial and error. Can one predict the effects of electrical stimulation on neural activity based on the circuit dynamics during spontaneous periods? Here we show that the effects of single-site micro-stimulation on ensemble activity in an alert monkey's prefrontal cortex can be predicted solely based on the ensemble's spontaneous activity. We first inferred the ensemble's causal flow based on the directed functional interactions inferred during spontaneous periods using convergent cross-mapping and showed that it uncovers a causal hierarchy betwee

SUBMITTER: Nejatbakhsh A 

PROVIDER: S-EPMC11636805 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature