A generalized logrank-type test for comparison of treatment regimes in sequential multiple assignment randomized trials.

ABSTRACT: The sequential multiple assignment randomized trial (SMART) is the ideal study design for the evaluation of multistage treatment regimes, which comprise sequential decision rules that recommend treatments for a patient at each of a series of decision points based on their evolving characteristics. A common goal is to compare the set of so-called embedded regimes represented in the design on the basis of a primary outcome of interest. In the study of chronic diseases and disorders, this outcome is often a time to an event, and a goal is to compare the distributions of the time-to-event outcome associated with each regime in the set. We present a general statistical framework in which we develop a logrank-type test for comparison of the survival distributions associated with regimes within a

SUBMITTER: Tsiatis AA 

PROVIDER: S-EPMC11636965 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature