Association of left atrial function with frailty: The Atherosclerosis Risk in Communities (ARIC) study.

ABSTRACT:

Background

Frailty is common in people with cardiovascular disease. Worse left atrial (LA) function is an independent risk factor for cardiovascular disease. However, whether worse LA function is associated with frailty is unclear.

Methods

We included 3292 older adults from the Atherosclerosis Risk in Communities study who were non-frail at baseline (visit 5, 2011-2013) and had LA function (reservoir, conduit, and contractile strain) measured from two-dimensional speckle-tracking echocardiography. LA stiffness index was calculated as a ratio of E/e' to LA reservoir strain. Frailty was defined using the validated Fried frailty phenotype. Incident frailty was assessed between 2016 and 2019 during two follow-up visits. LA function was analyzed as quintiles. Multivariable logist

SUBMITTER: Sun D 

PROVIDER: S-EPMC11637300 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature