Anti‑angiogenic effect of <i>Bryopsis plumosa</i>‑derived peptide via aquaporin 3 in non‑small cell lung cancer.

ABSTRACT: Developing novel anti‑angiogenic agents with minimal toxicity is notably challenging for cancer therapeutics. The discovery and development of peptides, whether derived from natural sources or synthesized, has potential for developing anti‑angiogenic agents characterized by their ability to penetrate cancer cells, high specificity and low toxicity. The present study identified a Bryopsis plumose‑derived anticancer and anti‑angiogenesis marine‑derived peptide 06 (MP06). A 22‑amino acid peptide was synthesized and conjugated with fluorescein isothiocyanate (FITC‑MP06) for intracellular localization in H1299 non‑small cell lung cancer cells. Regulatory effects of this peptide on the viability, migration and self‑renewal of lung cancer cells was assessed. Furthermore, anti‑angiogenic ef

SUBMITTER: Kim H 

PROVIDER: S-EPMC11637497 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature