Quantifying the strength of viral fitness trade-offs between hosts: a meta-analysis of pleiotropic fitness effects.

ABSTRACT: The range of hosts a given virus can infect is widely presumed to be limited by fitness trade-offs between alternative hosts. These fitness trade-offs may arise naturally due to antagonistic pleiotropy if mutations that increase fitness in one host tend to decrease fitness in alternate hosts. Yet there is also growing recognition that positive pleiotropy may be more common than previously appreciated. With positive pleiotropy, mutations have concordant fitness effects such that a beneficial mutation can simultaneously increase fitness in different hosts, providing a genetic mechanism by which selection can overcome fitness trade-offs. How readily evolution can overcome fitness trade-offs therefore depends on the overall distribution of mutational fitness effects between hosts, including th

SUBMITTER: Wang X' 

PROVIDER: S-EPMC11637551 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature