Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing Healthy Versus Typical Brain Ageing.

ABSTRACT: Ageing is a complex phenomenon affecting a wide range of coexisting biological processes. The homogeneity of the studied population is an essential parameter for valid interpretations of outcomes. The presented study capitalises on the MRI data available in the Human Connectome Project-Aging (HCP-A) and, within individuals over 55 years of age who passed the HCP-A section criteria, compares a subgroup of 37 apparently neurocognitively healthy individuals selected based on stringent criteria with 37 age and sex-matched individuals still representative of typical ageing but who did not pass the stringent definition of neurocognitively healthy. Specifically, structural scans, diffusion weighted imaging and T1w/T2w ratio were utilised. Furthermore, data of 26 HCP-A participants older than 90 y

SUBMITTER: Filip P 

PROVIDER: S-EPMC11637651 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature