Age-dependent differences in FIB-4 predictions of fibrosis in patients with MASLD referred from primary care.

ABSTRACT:

Background

Fibrosis 4 (FIB-4) is widely used to triage patients with metabolic dysfunction-associated steatotic liver disease. Given that age is part of FIB-4, higher scores may be expected in the elderly population. This led to the proposal of using a higher threshold of FIB-4 to triage patients aged ≥65. Our main objective is to evaluate how age modifies the association between the FIB-4 index and disease severity based on the vibration-controlled transient elastography (VCTE) "rule of 5s."

Methods

In this cross-sectional study, we prospectively analyzed data from a primary care referral pathway. We used liver stiffness measurement by VCTE as a reference standard for liver risk. We modeled with ordinal regression the exceedance probabilities of finding different liver stif

SUBMITTER: Sung S 

PROVIDER: S-EPMC11637747 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature