Determinants in the HTLV-1 Capsid Major Homology Region that are Critical for Virus Particle Assembly.

ABSTRACT: The Gag protein of retroviruses is the primary driver of virus particle assembly. Particle morphologies among retroviral genera are distinct, with intriguing differences observed relative to human immunodeficiency virus type 1 (HIV-1), particularly that of human T-cell leukemia virus type 1 (HTLV-1). In contrast to HIV-1 and other retroviruses where the capsid (CA) carboxy-terminal domain (CTD) possesses the key amino acid determinants involved in driving Gag-Gag interactions, we have previously demonstrated that the amino-terminal domain (NTD) encodes the key residues crucial for Gag multimerization and immature particle production. Here in this study, we sought to thoroughly interrogate the conserved HTLV-1 major homology region (MHR) of the CA_CTD to determine whether this reg

SUBMITTER: Yang H 

PROVIDER: S-EPMC11637902 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature