A multiscale discrete fiber model of failure in heterogeneous tissues: Applications to remodeled cerebral aneurysms.

ABSTRACT: Damage-accumulation failure models are broadly used to examine tissue property changes caused by mechanical loading. However, damage accumulation models are purely phenomenological. The underlying justification in using this type of model is often that damage occurs to the extracellular fibers and/or cells which changes the fundamental mechanical behavior of the system. In this work, we seek to align damage accumulation models with microstructural models to predict alterations in the mechanical behavior of biological materials that arise from structural heterogeneity associated with nonuniform remodeling of tissues. Further, we seek to extend this multiscale model toward assessing catastrophic failure events such as cerebral aneurysm rupture. First, we demonstrate that a model made up of l

SUBMITTER: Mahutga RR 

PROVIDER: S-EPMC11637903 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature