The association of lumbar intervertebral disc degeneration with low back pain is modified by underlying genetic propensity to pain.

ABSTRACT:

Background context

Associations between magnetic resonance imaging (MRI)-detected lumbar intervertebral disc degeneration (LDD) and LBP are often of modest magnitude. This association may be larger in specific patient subgroups.

Purpose

To examine whether the association between LDD and LBP is modified by underlying genetic predispositions to pain.

Study design

Cross-sectional study in UK Biobank (UKB) and Twins UK.

Patient samples

A genome-wide association study (GWAS) of the number of anatomical chronic pain locations was conducted in 347,538 UKB participants. The GWAS was used to develop a genome-wide polygenic risk score (PRS) in a holdout sample of 30,000 UKB participants. The PRS model was then used in analyses of 645 TwinsUK participants with standardize

SUBMITTER: Suri P 

PROVIDER: S-EPMC11637947 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature