Molecular Hallmarks of Prostate-specific Membrane Antigen in Treatment-naive Prostate Cancer.

ABSTRACT:

Background and objective

We characterized tumor prostate-specific membrane antigen (PSMA) levels as a reflection of cancer biology and treatment sensitivities for treatment-naïve prostate cancer.

Methods

We first correlated PSMA positron emission tomography (PET) maximum standardized uptake values (SUVmax) in primary prostate cancer with tumor FOLH1 (PSMA RNA abundance) to establish RNA as a proxy (n = 55). We then discovered and validated molecular pathways associated with PSMA RNA levels in two large primary tumor cohorts. We validated those associations in independent cohorts (18 total; 5684 tumor samples) to characterize the pathways and treatment responses associated with PSMA.

Key findings and limitations

PSMA RNA abundance correlates moderately with SUVmax (ρ =

SUBMITTER: Weiner AB 

PROVIDER: S-EPMC11637967 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature