Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization.

ABSTRACT:

Objectives

This study aimed to examine the causal relationships between peripheral immune cell counts and prostate cancer, adhering to Mendelian Randomization reporting guidelines for transparency and reproducibility.

Methods

In this study, bidirectional Mendelian randomization (MR) analysis, which includes MR-Egger, weighted median, weighted mode, and inverse variance weighted (IVW) approaches, was utilized to evaluate the bidirectional causal relationship between peripheral immune cell counts and the risk of PCa.

Results

The primary analysis using the IVW method suggests a potential causal association between basophil counts and the risk of prostate cancer (PCa), with an odds ratio (OR) of 1.111 and a 95% confidence interval (CI) of 1.011-1.222 (P = 0.028). C

SUBMITTER: Ren X 

PROVIDER: S-EPMC11638012 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature