Ephaptic conduction in tonic-clonic seizures.

ABSTRACT:

Objectives

Electroencephalograms (EEGs) or multi-unit activities (MUAs) of tonic-clonic seizures typically exhibit a distinct structure. After a preliminary phase (DC shift, spikes), the tonic phase is characterized by synchronized activity of numerous neurons, followed by the clonic phase, marked by a periodic sequence of spikes. However, the mechanisms underlying the transition from tonic to clonic phases remain poorly understood.

Methods

We employ a simple two-dimensional cellular automaton model to simulate seizure activity, specifically focusing on replicating the tonic-clonic transition. This model effectively illustrates the physical processes during the ictal phase and, more importantly, differentiates the roles of neurons' activity, identifying their origin as eithe

SUBMITTER: Rabinovitch A 

PROVIDER: S-EPMC11638044 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature