Assessment of corticospinal tract damage and cytokines response in early and late stages of acute unilateral brainstem infarction patients.

ABSTRACT:

Background

Acute brainstem infarction is associated with high morbidity and mortality, the integrity of corticospinal tract (CST) detected via diffusion tensor imaging (DTI) can assist in predicting the motor recovery of the patients. In addition to the damage caused by ischemia and reperfusion, sterile inflammation also contributes to the brain injury after stroke. However, the changes in CST integrity detected by DTI in acute brainstem infarction have yet to be fully elucidated, and it is still unclear whether sterile inflammation can cause damage to the CST.

Methods

In this study, the acute brainstem infarction patients in the early (EABI patients, n = 19) and late (LABI patients, n = 21) stages and healthy controls (HCs, n = 22) are employed. The probabilistic tractograp

SUBMITTER: Shi M 

PROVIDER: S-EPMC11638050 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature