SOX-5 Transcription Factor: a Novel Psoriatic Autoantigen Preferentially Found in Women.

ABSTRACT:

Objective

Adaptive immunity mediates psoriatic disease pathogenesis. We aimed to identify novel psoriatic autoantigens and their phenotypic associations in deeply characterized patient cohorts.

Methods

Sera from psoriatic arthritis (PsA) patients were used for autoantibody discovery. Immunoprecipitations performed with cell lysates were on-bead digested, and autoantigens were identified by mass spectrometry. Prevalence and clinical features associated with anti-SRY-Box transcription factor-D (SOX-D) antibodies were determined by screening discovery cohorts of patients with PsA (n = 135), patients with psoriasis without PsA (n = 24), and healthy controls (n = 41). A PsA validation cohort (n = 325) and disease control samples of individuals with rheumatoid arthritis (RA; n = 6

SUBMITTER: Orbai AM 

PROVIDER: S-EPMC11638130 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature