Single-Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjogren Disease.

ABSTRACT:

Objective

Sjögren disease (SjD) is an autoimmune condition characterized by the dysfunction of the salivary and lacrimal glands. The study aimed to decipher the pathogenic cell populations and their immunologic pathways in the salivary glands. We further determined the therapeutic effect of inhibiting dedicator of cytokinesis 2 (DOCK2) shared by novel clusters of CD8⁺ T cells in an SjD mouse model.

Methods

This study employed single-cell RNA sequencing to examine the composition and dynamics of immune cells in the salivary glands of SjD mice. By analyzing the transcriptomic data and employing clustering analysis, a specific target was identified, leading to the treatment of mice with a targeted inhibitor.

Results

The results showed diverse immune cell types

SUBMITTER: Shen Y 

PROVIDER: S-EPMC11638132 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature