The safety and efficacy of applying a high-current temporal interference electrical stimulation in humans.

ABSTRACT:

Background

Temporal interference electrical stimulation (TI) is promise in targeting deep brain regions focally. However, limited electric field intensity challenges its efficacy.

Objective

This study aimed to introduce a high-current TI electrical stimulation protocol to enhance its intensity and evaluate its safety and efficacy when applied to the primary motor cortex (M1) in the human brain.

Methods

Safety assessments included a battery of biochemical and neuropsychological tests (NSE, MoCA, PPT, VAMS-R, and SAS measurements), 5-min resting-state electroencephalography (EEG) recordings before and after 30-min high-current TI electrical stimulation sessions (20 Hz, 70 Hz, sham). Adverse reactions were also documented post-stimulation. Efficacy evaluations involved t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11638170 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature