Transcriptional patterns of brain structural abnormalities in CSVD-related cognitive impairment.

ABSTRACT:

Background

Brain structural abnormalities have been associated with cognitive impairment in individuals with small cerebral vascular disease (CSVD). However, the molecular and cellular factors making the different brain structural regions more vulnerable to CSVD-related cognitive impairment remain largely unknown.

Materials and methods

Voxel-based morphology (VBM) was performed on the structural magnetic resonance imaging data of 46 CSVD-related cognitive impairment and 73 healthy controls to analyze and compare the gray matter volume (GMV) between the 2 groups. Transcriptome-neuroimaging spatial correlation analysis was carried out in combination with the Allen Human Brain Atlas to explore gene expression profiles associated with changes in cortical morphology in CSVD-relat

SUBMITTER: Mao H 

PROVIDER: S-EPMC11638219 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature