Bacillus coagulans MF-06 alleviates intestinal mucosal barrier from damage in chicks infected with Salmonella pullorum via activating the Wnt/β-catenin pathway.

ABSTRACT:

Introduction

This study aimed to assess the protective efficacy of Bacillus coagulans MF-06 as a potential alternative to antibiotics in mitigating intestinal mucosal damage in chicks infected with Salmonella pullorum.

Methods

A total of 150 one-day-old SPF chicks were selected and randomly divided into five groups: control group (CK), probiotics group (EM), probiotics treatment group (PT), antibiotic treatment group (AT), Salmonella pullorum group (SI), CK, AT and SI groups were fed a basal diet, EM and PT groups were fed a basal diet supplemented with 1.0 × 10⁸ CFU/g Bacillus coagulans; PT, AT and SI groups were gavaged with 1.0 × 10⁹ CFU/0.5 mL Salmonella pullorum at 7 days of age; AT group were fed with 0.375 g/kg

SUBMITTER: Ma L 

PROVIDER: S-EPMC11638242 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature