Neurobeachin regulates receptor downscaling at GABAergic inhibitory synapses in a protein kinase A-dependent manner.

ABSTRACT: GABAergic synapses critically modulate neuronal excitability, and plastic changes in inhibitory synaptic strength require reversible interactions between GABA_A receptors (GABA_ARs) and their postsynaptic anchor gephyrin. Inhibitory long-term potentiation (LTP) depends on the postsynaptic recruitment of gephyrin and GABA_ARs, whereas the neurotransmitter GABA can induce synaptic removal of GABA_ARs. However, the mechanisms and players underlying plastic adaptation of synaptic strength are incompletely understood. Here we show that neurobeachin (Nbea), a receptor trafficking protein, is a component of inhibitory synapses, interacts with gephyrin and regulates the downscaling of inhibitory synaptic transmission. We found that the recruitment of Nbea to

SUBMITTER: Lutzenkirchen FP 

PROVIDER: S-EPMC11638247 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature