Incidence and mortality of ALS: a 42-year population-based nationwide study.

ABSTRACT:

Background and aim

Recent studies have suggested that the incidence rate (IR) and the rate of death (MR) of amyotrophic lateral sclerosis (ALS) are increasing. Still, it remains unclear whether this is due to improved case ascertainment or represents a true increase. We examined the development in the incidence and mortality of ALS in Denmark for 42 years.

Methods

We retrieved individual-level data of all patients aged above 18 years with first-time ALS diagnosed at any Danish department of neurology. The IR and MR were calculated based on data from 1980 to 2021, stratified by gender and age.

Results

We identified 5,943 patients with ALS and identified a total of 5,069 deaths in the nationwide population. Overall, the IR was 3.4 per 100,000 persons per year (95% CI 3.

SUBMITTER: Levison LS 

PROVIDER: S-EPMC11638285 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature