Myelin basic protein and TREM2 quantification in the CSF of patients with Multiple System Atrophy and other Parkinsonian conditions.

ABSTRACT:

Background

It is well known that myelin disruption and neuroinflammation are early and distinct pathological hallmarks in multiple system atrophy (MSA) as well as in idiopathic Parkinson's disease and in other atypical Parkinsonian syndromes. The objective of this study was to assess the value of non-neuronal biomarker candidates that reflect myelin disruption and neuroinflammation.

Methods

Myelin basic protein (MBP) and the soluble form of TREM2 were quantified in a comprehensive movement disorder cohort from two different neurological centers, comprising a total of 171 CSF samples. Commercially available ELISA systems were employed for quantification.

Results

The results of the MBP analysis revealed a significant increase in cerebrospinal fluid (CSF) MBP levels in a

SUBMITTER: Maass F 

PROVIDER: S-EPMC11638341 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature