Exploring clinical chemistry markers in amyotrophic lateral sclerosis: insights into survival and disease trajectories.

ABSTRACT:

Objective

Commonly measured clinical chemistry markers might be indicative of survival and disease progression in amyotrophic lateral sclerosis (ALS).

Methods

In a cohort study of 270 ALS patients diagnosed from April 2014 to May 2021 in Stockholm, Sweden, we examined the link between 29 clinical chemistry markers at diagnosis and mortality risk at 6 months, 1 year, and 3 years after diagnosis. Summary variables from exploratory factor analysis (EFA) assessed the markers' collective impact on survival. We integrated ALS functional rating scale-revised (ALSFRS-R) scores with survival data using a joint latent class model to identify patterns of functional decline. Multinomial logistic regression determined how the EFA-derived factors predicted the decline trajectories post-di

SUBMITTER: Psychogios I 

PROVIDER: S-EPMC11638388 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature