Scaling and interpreting treatment effects in clinical trials using restricted mean survival time.

ABSTRACT:

Background

Restricted mean survival time is the expected duration of survival up to a chosen time of restriction τ. For comparison studies, the difference in restricted mean survival times between two groups provides a summary measure of the treatment effect that is free of assumptions regarding the relative shape of the two survival curves, such as proportional hazards. However, it can be difficult to judge the magnitude of the effect from a comparison of restricted means due to the truncation of observation at time τ.

Methods

In this article, we describe additional ways of expressing the treatment effect based on restricted means that can be helpful in this regard. These include the ratio of restricted means, the ratio of life-years (or time) lost, and the average integrat

SUBMITTER: Karrison T 

PROVIDER: S-EPMC11638402 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature