Preoperative detection of extraprostatic tumor extension in patients with primary prostate cancer utilizing [⁶⁸Ga]Ga-PSMA-11 PET/MRI.

ABSTRACT:

Objectives

Radical prostatectomy (RP) is a common intervention in patients with localized prostate cancer (PCa), with nerve-sparing RP recommended to reduce adverse effects on patient quality of life. Accurate pre-operative detection of extraprostatic extension (EPE) remains challenging, often leading to the application of suboptimal treatment. The aim of this study was to enhance pre-operative EPE detection through multimodal data integration using explainable machine learning (ML).

Methods

Patients with newly diagnosed PCa who underwent [⁶⁸Ga]Ga-PSMA-11 PET/MRI and subsequent RP were recruited retrospectively from two time ranges for training, cross-validation, and independent validation. The presence of EPE was measured from post-surgical histopathology and pre

SUBMITTER: Spielvogel CP 

PROVIDER: S-EPMC11638435 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature