Development and Validation of the Hospital Medicine Safety Sepsis Initiative Mortality Model.

ABSTRACT:

Background

When comparing outcomes after sepsis, it is essential to account for patient case mix to make fair comparisons. We developed a model to assess risk-adjusted 30-day mortality in the Michigan Hospital Medicine Safety sepsis initiative (HMS-Sepsis).

Research question

Can HMS-Sepsis registry data adequately predict risk of 30-day mortality? Do performance assessments using adjusted vs unadjusted data differ?

Study design and methods

Retrospective cohort of community-onset sepsis hospitalizations in the HMS-Sepsis registry (April 2022-September 2023), with split derivation (70%) and validation (30%) cohorts. We fit a risk-adjustment model (HMS-Sepsis mortality model) incorporating acute physiologic, demographic, and baseline health data and assessed model perfor

SUBMITTER: Prescott HC 

PROVIDER: S-EPMC11638544 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature