Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers.

ABSTRACT:

Background

Cefiderocol may potentially be used to treat skin and soft tissue infections (SSTIs). However, the pharmacokinetics of cefiderocol in human soft tissues have not yet been determined. The objective of the present PK study was to investigate whether target-site concentrations of cefiderocol are sufficiently high for the treatment of SSTIs.

Methods

In this pharmacokinetic study, a single intravenous dose of 2 g cefiderocol was administered to eight healthy male volunteers. Drug concentrations were determined in plasma, muscle and subcutis over 8 h. Free plasma concentrations were calculated using the plasma protein binding determined with ultrafiltration. Free tissue concentrations were obtained using microdialysis. Penetration ratios were calculated as AUC0-8h_free_

SUBMITTER: Sanz-Codina M 

PROVIDER: S-EPMC11638555 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature