The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases.

ABSTRACT:

Background

To investigate the relationship between the triglyceride and glucose (TyG) index and cognitive impairment (CI).

Methods

Five authoritative databases were systematically searched for potentially relevant studies on 'TyG index' and 'CI' from inception to 27 April 2024. Two representative databases from the United Kingdom and United States were also included. We used the PICOS criteria to select available articles. All data was combined to compute Odd Ratios (ORs).

Results

15 studies were included in the meta-analysis (participants: 5604303). The pooled effect sizes demonstrate that individuals with a high TyG index exhibit a significantly elevated risk of CI compared to those with a low TyG index (OR = 2.16, 95%CI: 1.51; 3.08, p < 0.001). The subgroup

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11638587 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature