Effects of parietal iTBS on resting-state effective connectivity within the frontoparietal network in patients with schizophrenia: An fMRI study.

ABSTRACT:

Background

Although intermittent theta burst stimulation (iTBS) has shown effectiveness in addressing working memory (WM) deficits in individuals with schizophrenia (SZ), the current body of evidence is limited and the specific mechanisms involved remain unclear. Therefore, this pilot fMRI study aimed to examine the efficacy of parietal iTBS in ameliorating WM impairments and explore its influence on the resting-state effective connectivity within the frontoparietal network in patients with SZ.

Method

A total of 48 patients diagnosed with SZ were randomly assigned to an active or sham iTBS group and underwent 20 sessions of active or sham iTBS over 4 weeks. Subsequently, all patients underwent cognitive tests, clinical symptom assessments, and resting-state functional MRI (r

SUBMITTER: Li L 

PROVIDER: S-EPMC11638604 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature