Improving diagnosis in patients with obstetric antiphospholipid syndrome through the evaluation of non-criteria antibodies.

ABSTRACT:

Objectives

Antiphospholipid syndrome (APS) is an autoimmune disease driven by antiphospholipid antibodies (aPL). Currently, APS diagnosis requires a combination of clinical manifestations (thrombosis and/or obstetric morbidity) and the persistent presence of at least one criteria aPL: anti-cardiolipin antibodies (aCL), anti-β2-glycoprotein I antibodies (aβ2GPI) or lupus anticoagulant (LA). Patients with suggestive obstetric symptoms but lacking criteria aPL face diagnostic challenges. Non-criteria aPL screening may enhance discrimination. This study proposes a classification incorporating both criteria and non-criteria antibodies to improve obstetric APS diagnosis.

Methods

Blood samples from non-pregnant women (n = 68) with a history of vascular, obstetric, or vascula

SUBMITTER: Alvarez D 

PROVIDER: S-EPMC11638733 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature