Investigating the combinatory effect of <i>Sclerocarya birrea</i> with doxorubicin against selected colorectal cancer cell lines.

ABSTRACT:

Introduction

Colorectal cancer incidences continue to increase annually, worldwide. Herbal plants with antiproliferative properties received research interest as agents that can be adjuvant therapies with chemotherapy drugs to enhance their efficacy and reverse drug resistance.

Methods

Sclerocarya birrea ethanolic (SBE) and aqueous (SBW) extracts combined with doxorubicin (DOX) against drug-sensitive and drug-resistant colorectal cancer cells were investigated for their potential adjuvant and drug resistance reversal. The extracts were assessed for their potential anticancer activities on HCT15 and HT29 cell lines as well as their doxorubicin potentiating and drug resistance reversal effects respectively. The extracts were assessed for their cytotoxicity on normal 3T3

SUBMITTER: Nxasana TH 

PROVIDER: S-EPMC11638844 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature