Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase.

ABSTRACT:

Abstract

The tumor architecture of high-grade gliomas is shaped by tumor cell necrosis, invasive growth, and the leakage of a fibrin-rich edema from poorly organized tumor blood vessels. In this study, we demonstrate a marked upregulation of clot formation in the interstitial spaces of tumor tissues from patients with glioblastoma (GBM) whereas a tumor-free brain is essentially devoid of fibrin. The accumulation of fibrin in tumor interstitial spaces is functionally relevant as we demonstrate increased infiltration and growth of primary GBM cells after embedding in a 3-dimensional matrix made of fibrin ex vivo. Additionally, we detected accelerated tumor growth after implanting GBM cells together with clotted plasma in brains of immunodeficient mice whereas GBM development in clott

SUBMITTER: Knowles LM 

PROVIDER: S-EPMC11638908 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature