Astrocytic mitochondrial transfer to brain endothelial cells and pericytes <i>in vivo</i> increases with aging.

ABSTRACT: Intercellular mitochondrial transfer (IMT) is an intriguing biological phenomenon where mitochondria are transferred between different cells and notably, cell types. IMT is physiological, occurring in normal conditions, but also is utilized to deliver healthy mitochondria to cells in distress. Transferred mitochondria can be integrated to improve cellular metabolism, and mitochondrial function. Research on the mitochondrial transfer axis between astrocytes and brain capillaries in vivo is limited by the cellular heterogeneity of the neurovascular unit. To this end, we developed an inducible mouse model that expresses mitochondrial Dendra2 only in astrocytes and then isolated brain capillaries to remove all intact astrocytes. This method allows the visualization of in vivo ast

SUBMITTER: Velmurugan GV 

PROVIDER: S-EPMC11638933 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature