Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines.

ABSTRACT: Population-level genetic studies are overwhelmingly biased toward European ancestries. Transferring genetic predictions from European ancestries to other ancestries results in a substantial loss of accuracy. Yet, it remains unclear how much various genetic factors, such as causal effect differences, linkage disequilibrium (LD) differences, or allele frequency differences, contribute to the loss of prediction accuracy across ancestries. In this study, we used gene expression levels in lymphoblastoid cell lines to understand how much each genetic factor contributes to lowered portability of gene expression prediction from European to African ancestries. We found that cis-genetic effects on gene expression are highly similar between European and African individuals. However, we found that all

SUBMITTER: Saitou M 

PROVIDER: S-EPMC11639078 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature