Comparative analysis of predicted DNA secondary structures infers complex human centromere topology.

ABSTRACT: Secondary structures are non-canonical arrangements of nucleic acids due to intra-strand interactions, including base pairing, stacking, or other higher-order features that deviate from the standard double-helical conformation. While these structures are extensively studied in RNA, they can also form when DNA becomes single stranded, creating topological roadblocks that can impact essential DNA-based processes such as replication, transcription, and repair, ultimately affecting genome stability. The availability of a complete linear sequence of human genomes, including repetitive loci, enables the prediction of DNA secondary structures comparing across various regions. Here, we evaluate the intrinsic properties of linear single-stranded DNA sequences derived from sampling specialized human

SUBMITTER: Chittoor SS 

PROVIDER: S-EPMC11639080 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature